
HKU Chemists Harness Light to Build 3D Molecular Structures for Drug Discovery
Researchers from the Department of Chemistry at The University of Hong Kong (HKU), led by Professor Jian HE and collaborators, have developed a new light-driven method for constructing three-dimensional molecular building blocks that could give medicinal chemists greater flexibility in designing new drug candidates. The approach broadens the range of starting materials that can be used while suppressing unwanted polymerisation, overcoming key limitations of existing synthetic methods. The findings have been published in Nature Chemistry. Benzene rings are among the most common structural building blocks in medicines. They are chemically stable and provide a useful framework for positioning other functional groups within a drug molecule. However, their flat and relatively lipophilic nature can sometimes contribute to undesirable properties, such as poor water solubility or less favourable interactions with biological targets. Medicinal chemists are therefore increasingly exploring three-dimensional alternatives that can replace benzene rings while performing a similar structural role in drug molecules. One promising class is bicyclo[2.1.1]hexanes, or BCHs. Their compact, three-dimensional shape offers researchers another way to fine-tune the shape and properties of drug molecules, potentially improving characteristics such as solubility, selectivity and metabolic stability. One important route to BCHs involves combining bicyclo[1.1.0]butanes or BCBs with alkenes. BCBs are highly strained small-ring molecules that serve as useful starting materials for building more complex three-dimensional structures. However, synthesising structurally diverse BCHs has remained difficult. Existing methods may work only with a limited range of starting materials and can also trigger unwanted polymerisation or suffer from catalyst instability. Professor He’s team and their collaborators have now developed a new class of copper(I) photosensitisers that use visible light to drive this reaction. After absorbing light, the copper complex transfers energy to one of the starting materials, enabling BCH structures to form in a more controlled manner. The new strategy expands the range of starting materials that can be used and allows chemists to control where different chemical groups are positioned on the BCH scaffold. The team also demonstrated gram-scale synthesis and further modification of the resulting BCHs with a variety of functional groups, highlighting the method’s potential usefulness in medicinal chemistry and drug development. Professor Jian He expressed optimism about the potential impact of this discovery, stating, “The heteroleptic copper(I) photosensitisers developed by our team provide a new approach to the efficient and selective synthesis of BCHs. By modulating the triplet energy levels of copper complexes, we have effectively suppressed polymerisation side reactions and expanded the substrate scope to include electron-deficient alkenes, enynes, dienes, and even aliphatic alkenes. This opens new opportunities for sustainable chemical production and the development of more diverse drug candidates.” Catalytic photosensitisation strategies for the synthesis of BCH bioisosteres via intermolecular cycloadditions. Image adapted from Tang et al., Nature Chemistry (2026).
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HKU Study Reveals How Atmospheric Dryness Constrains Typhoon Rainfall, Leading to Lower-Than-Expected Increases
Under global warming, scientists have widely expected tropical cyclones (including typhoons and hurricanes) to bring more intense and frequent rainfall. The underlying physics seems intuitive: rising temperatures allow the atmosphere to hold more moisture, which, combined with intensifying storms, should theoretically trigger more destructive downpours. However, when researchers analyse climate model projections, they encounter a puzzling phenomenon: some models project rainfall increases that are far lower than what thermodynamics alone would predict. This uncertainty has long hindered the scientific community’s ability to accurately project future tropical cyclone precipitation and assess associated flood risks. Recently, a new study led by The University of Hong Kong (HKU) and Imperial College London (ICL) has uncovered a key missing piece of the puzzle: increasing atmospheric dryness. Published in Nature Geoscience, the work reveals that while a warmer atmosphere can indeed hold more moisture, it also becomes drier in a way that suppresses rainfall—effectively acting as a “brake” on tropical cyclone precipitation. Widening Atmospheric Unsaturation Obstructs Cloud Formation and Accelerates Evaporation The team, consisting of Professor Dazhi XI and Dr Jianan CHEN from the HKU Department of Earth and Planetary Sciences, and Professor Ralf TOUMI from ICL, analysed climate simulations, satellite observations, and reanalysis data. They found that as the climate warms, tropical cyclones become less efficient at converting moisture into rainfall. The team pointed out that the key lies in a physical mechanism known as the “column saturation deficit”—the gap between the actual amount of water vapour in the atmosphere and its level at complete saturation (the threshold for precipitation). Generally, rainfall occurs as water vapour condenses into cloud droplets, coalesces into raindrops, and falls to the ground. Under a warming climate, however, the atmosphere’s moisture-holding capacity increases exponentially. Consequently, even if relative humidity remains constant, the gap to “complete saturation” widens significantly, meaning the air becomes substantially drier. This dryness can possibly trigger two effects: Pre-landing Evaporation: Raindrops that condense at high altitudes in a typhoon are rapidly evaporated by dry air in the lower and middle troposphere during their descent, preventing them from reaching the ground. Inhibition of Condensation: As dry environmental air is entrained into the typhoon’s updraft, it dilutes the moisture supply, suppressing cloud and rain formation at the source. This constraining effect of atmospheric dryness is potent enough to offset the rainfall increases driven by storm intensification. This offers a robust physical explanation for why many climate models project rainfall increases that are consistently lower than traditional theoretical calculations. Pioneering a “Unified Assessment Framework” The study also proposes a unified framework for understanding tropical cyclone rainfall. It shows that rainfall depends not only on storm intensity and the amount of water vapour in the atmosphere, but also on precipitation efficiency—how efficiently that moisture is converted into rain. Two opposing effects in a warming climate shape this efficiency: greater storm intensity tends to boost it, while increased atmospheric dryness tends to suppress it. Although atmospheric dryness dominates in some climate models, this framework does not rule out an increase in precipitation efficiency if future storm intensification outweighs the suppressive effect of atmospheric dryness. The findings could have important practical implications. For coastal communities, disaster managers, and infrastructure planners, more accurate projections of rainfall from future hurricanes and typhoons are critical for flood protection, evacuation planning, and climate resilience. By accounting for the effect of atmospheric dryness, the new framework could improve rainfall and flood-risk assessments and support better-informed climate adaptation planning. The study also notes that global climate models do not fully capture some fine-scale processes. Future high-resolution simulations will therefore be needed to refine the projections. Nevertheless, multiple datasets and models consistently show that greater atmospheric dryness reduces rainfall efficiency. This robust negative correlation underscores that atmospheric dryness is a critical thermodynamic constraint that must be incorporated into future climate projections. For details of the research, please refer to the journal paper “Future tropical cyclone rainfall constrained by increased atmospheric dryness”.
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