
HKU Unveils Innovative Portable AI Optical Sensing Device for Rapid, Non-Invasive Cancer Risk Detection
Cancer remains a critical health challenge globally. In 2023, the Hong Kong Cancer Registry recorded close to 38,000 new cancer cases and nearly 15,000 cancer-related deaths. Faced with the continuously rising number of cases, society's demand for detection solutions that can be used for early screening and long-term monitoring is also increasing accordingly. Currently researchers are developing a range of innovative detection approaches, aiming to complement current techniques and enable a more comprehensive framework for cancer detection, better supporting public health monitoring needs. Professor Chi-Ming CHE, Zhou Guangzhao Professor in Natural Sciences and Chair Professor of Chemistry, Department of Chemistry, Faculty of Science, The University of Hong Kong (HKU), and the Laboratory for Synthetic Chemistry and Chemical Biology Limited (LSCCB), and Dr Wei Liu, Department of Chemistry, Faculty of Science, HKU, and LSCCB, have developed an innovative portable AI-enabled optical sensing device that enables rapid, non-invasive cancer risk detection using just a saliva sample. This innovative technology integrates advanced chemical sensing with artificial intelligence and was awarded a Gold Medal with Congratulations of the Jury at the 51st International Exhibition of Inventions of Geneva (2026), recognising its scientific excellence and strong potential for practical application. This innovative technology was awarded a Gold Medal with Congratulations of the Jury at the 51st International Exhibition of Inventions of Geneva (2026) Non-Invasive, Fast and Accessible Detection This newly developed device represents a major advancement in cancer detection by offering a non-invasive, fast and user-friendly alternative to traditional methods. Designed for portability and ease of use, the device allows individuals to conduct tests independently through a mobile application, without the need for specialised medical personnel or large-scale equipment. The detection process is completed in under 10 minutes. The schematic diagram showing the detection process of this innovative technology. Professor Che said, “Using saliva instead of tissue samples enables us to minimise discomfort while reducing the risks associated with invasive procedures. This makes it a promising early-stage auxiliary detection tool for hospital examinations. Its convenience makes it particularly suitable for high-risk individuals, including those with a family history of cancer and patients requiring regular follow-up after treatment. Innovative Luminescent Technology Meets Artificial Intelligence At the core of this innovation is a novel class of luminescent metal complexes invented by Professor Che, which selectively bind to DNA damage sites – key indicators associated with cancer development. When bound to damaged DNA, especially mismatched DNA, the complexes exhibit a dramatic change in photo-luminescence compared to normal DNA, enabling detection using a highly sensitive device. The optical signal is captured by a miniature spectrometer, engineered by Dr Wei Liu, and then translated into actionable insights through AI-powered analysis. The integration of advanced chemical sensing with artificial intelligence creates a powerful platform that bridges molecular diagnostics and digital health technologies. The innovative technologies: (a) The luminescent metal complexes that selectively bind to mismatched DNA, developed by Prof. Che; (b) The portable spectral device that captures the luminescent signal, developed by Dr. Liu. From Laboratory Breakthrough to Clinical Impact Professor Che emphasised, “This device is not intended to replace clinical diagnoses, but rather to serve as a complementary tool for rapid detection and continuous monitoring.” Preliminary studies involving patients with breast cancer and nasopharyngeal carcinoma have demonstrated strong capability in distinguishing between healthy and affected individuals. The research team is currently collaborating with clinical oncologists across multiple hospitals to conduct larger-scale validation studies covering a broader spectrum of cancer types. This initiative reflects HKU and LSCCB’s commitment to translating cutting-edge scientific research into practical solutions that address pressing healthcare challenges and deliver meaningful societal impact.
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HKU Nobel Laureate Professor Ferenc Krausz Elected as International Member of U.S. National Academy of Sciences
Professor Ferenc KRAUSZ, Chair Professor of Laser Physics in the Department of Physics, Faculty of Science at The University of Hong Kong (HKU), has been elected as an International Member of the National Academy of Sciences, USA (NAS), in recognition of his outstanding contributions to ultrafast laser science and attosecond physics. Professor Xiang ZHANG, President and Vice-Chancellor of HKU extended his congratulations, remarking, “Professor Krausz’s work has fundamentally redefined the boundaries of what we can measure, allowing us to witness the swiftest processes in the physical world. His election is a profound recognition of a scientist who looks where others once thought it was impossible to see. At HKU, we strive to be a home for the pursuit of fundamental truths, with a view to inspiring the next generation of scholars to push beyond the established limits of human knowledge.” The NAS recently announced the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original research. Reflecting on the honour, Professor Krausz said: “I am deeply grateful for this recognition from the National Academy of Sciences. It reflects many years of collaborative work, and I look forward to continuing to advance attosecond science and its applications.” Professor Krausz, who was awarded the Nobel Prize in Physics in 2023, is widely recognised for pioneering attosecond metrology, enabling the observation of electron dynamics on their natural timescales. His work has opened new frontiers in physics, chemistry, and materials science, with far-reaching implications for both fundamental research and technological innovation. About Professor Ferenc Krausz A Hungarian-born Austrian physicist and a pioneer of attosecond science, Professor Krausz earned his doctorate in laser physics with distinction from the Vienna University of Technology in 1991 and completed his habilitation in 1993. He continued his academic career at the Vienna University of Technology, where he joined as an assistant professor in 1996 and was promoted to full professor in 1999. Since 2004, he has been holding leadership roles as Director of the Max Planck Institute of Quantum Optics and as Chair of Experimental Physics - Laser Physics at Ludwig Maximilian University in Munich. He founded the Centre for Advanced Laser Applications in Munich in 2015 and the Center for Molecular Fingerprinting (CMF) in 2019. With CMF (cmf.hu), he took the lead in establishing a new type of large-scale prospective longitudinal cohort study, “h4h.hu”, aimed at laying the foundations for personalised preventive healthcare. To this end, he recently initiated a global alliance, “Protecting.Health”, bringing together CMF, LMU and HKU. His accolades include the Nobel Prize in Physics (2023), awarded for his experiments with attosecond pulses of light, which he shared with Pierre Agostini and Anne L’Huillier. He is also a recipient of the BBVA Foundation Frontiers of Knowledge Award (2023), the Wolf Prize in Physics (2022), and the King Faisal International Prize for Science (2013). His work has contributed to advances in precision measurement and a deeper understanding of fundamental processes in matter.
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