ST0206New
You Are What You Eat: How Nutrition Can Influence Your Genes?By School of Biological Sciences
Level: F.5 – F.6
HKDSE Related Subject(s): Biology, ChemistryWhat we eat can affect how our bodies work. Nutritional genomics looks at how food and genes interact. Some nutrients can change how genes work, while genes can also affect how people respond to different foods. Epigenetics is about changes in gene activity that do not change the DNA itself. These changes can be passed on when cells divide. Research suggests that the food choices of parents may even affect the health of their children and grandchildren. So, we are not only shaped by what we eat, but also by what our parents and grandparents ate. |
ST0208New
Dish Soap or Delicacy? What Your DNA Says About CorianderBy School of Biomedical Sciences
Level: F.4 – F.6
HKDSE Related Subject(s): BiologyDo you love coriander, or do you think it tastes like dish soap? The answer is not just in your mouth - it is written in your DNA! In this talk, we will explore the world of genetics and bioinformatics to understand how Single Nucleotide Polymorphisms (SNPs) can shape our unique human traits. We will step into the shoes of a genetics detective, learning how to read mRNA sequences and use real-world computational databases to hunt down the gene(s) responsible for our food preferences. Beyond coriander, we will discuss how these same research tools are revolutionising modern medicine. |
ST0211New
From Model Organisms To Understanding Human DiseasesBy School of Biological Sciences
Level: F.4 – F.6
HKDSE Related Subject(s): Biology, ChemistryScientists use model organisms, including yeast, worms, flies, frogs, zebrafish and mice, to study genes and pathways vital for cell survival, development and connected to human diseases, such as Down syndrome, Alzheimer’s disease, cancers, and even aging. In this talk, the speaker will share how genes and cellular processes are conserved, along with examples showing how basic, foundational discoveries can shape healthcare over the long term. The speaker will also examine how sequencing, transgenics, and genome editing technologies create new opportunities to probe complex disease mechanisms, improve diagnoses, and develop therapeutic strategies and drugs. Further perspectives from different stakeholders and the ethical considerations involved will also be discussed. |
ST0004
Understanding CancerBy School of Biomedical Sciences
Level: F.4 – F.6
HKDSE Related Subject(s): BiologyCancer is a genetic disease caused by alterations in oncogenes and other related genes. In this talk, the speaker will first introduce the ground-breaking discovery of oncogenes, which was awarded the Nobel Prize in 1989. How a normal gene can become an oncogene through mutations, and the underlying mechanisms, will be explained. Examples will be provided to illustrate how our understanding of oncogene function has led to a revolution in the design and development of highly specific and effective anti-cancer drugs that target oncogenes. This new form of individualized treatment is known as precision medicine. |
ST0183
Understanding COVID-19 and SARS-CoV-2By School of Biomedical Sciences
Level: F.4 – F.6
HKDSE Related Subject(s): BiologyThe pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still ongoing. In this talk, the speaker will give a brief introduction to the science of COVID-19 and SARS-CoV-2. The talk will cover all important areas, including the origin of SARS-CoV-2, the life cycle of the virus, COVID-19 disease, diagnosis, treatment, and vaccine development. In particular, the talk will highlight how HKU scientists have made a difference in the fight against COVID-19. It will also address many key questions, such as whether SARS-CoV-2 is man-made, how vaccines are developed, and how safe and effective existing vaccines are. |
ST0184
Stem Cell Therapies – Reality vs. HypeBy School of Biomedical Sciences
Level: F.4 – F.6
HKDSE Related Subject(s): BiologyWhat are stem cells? Why the doctors and scientists are so excited about stem cells? Recently, biomedical scientists reported the creation of the first human synthetic model embryos. Such breakthroughs could help research genetic disorders but raise serious ethical and legal concerns. In the first part of this talk, the speaker will discuss the unique features of stem cells, the different types of stem cells and some of their potential applications (i.e., hopes). The second part of the talk will focus on ethical issues in stem cell research and therapy. |
ST0198
Learn from Nature, Drug Discovery from Tiny MicrobeBy Department of Chemistry
Level: F.4 – F.6
HKDSE Related Subject(s): Biology, ChemistryThe alarming increase in antibiotic-resistant bacteria, known as "superbugs," is a significant global health issue. In this talk, the speaker will provide a concise overview of antibiotic resistance and the cutting-edge strategies used to develop new antibiotics to fight these dangerous pathogens. Essential topics covered include the origins of antibiotic resistance, the discovery of antibiotics, and the innovative methods employed by HKU scientists to combat antibiotic resistance. The talk will discuss how we can draw inspiration from nature in discovering new antibiotics by learning from the diverse chemicals produced by microbes. Additionally, it will emphasise using state-of-the-art techniques such as AI, big data, synthetic chemistry, and synthetic biology in the quest for new antibiotics. This talk aims to motivate and inform secondary school students about the vital role of scientific progress in tackling global health challenges. |
ST0201
Exploring our Gene: Drug Development to Combat CancersBy Department of Chemistry
Level: F.4 – F.6
HKDSE Related Subject(s): Biology, ChemistryCancers has long been the major cause of mortality in Hong Kong. Genomic and biochemical studies have increasingly played an important role in prognosis, diagnosis, and drug development against a variety of cancers. In this talk, an overview of the nature and risk factors for cancers will be reviewed. Methods to identify the potential biomarkers and targets by DNA sequencing and biomolecular investigations will be shared. Some steps of drug development including structureactivity relationships (SAR), pharmacophore identifications, lead optimisations and pharmacokinetic studies will be covered. Examples of how drug molecules act against different targets in cancers will be shown for students to appreciate the mechanism of action of potential drug candidates based on scientific research. |