Professor LI, Xuechen
Morningside Professorship in Chemical Biology & Professor, Department of Chemistry, Faculty of Science, HKU
B.Sc. (Nankai;); M.Sc. (Alberta); Ph.D. 2003-2006 (Harvard University)
- [javascript protected email address]
- 3917 4992
- 405 Chong Yuet Ming Chemistry Building, University of Hong Kong, Pokfulam Road, Hong Kong
Teaching area:
- Organic Chemistry
Research area:
- Chemical Biology
- Glycosylation and Therapeutic Applicationsm Carbonhydrate Chemistry
- Protein Chemistry
Publications:
- Liu, H.; Li, X.* Serine/Threonine Ligation: Origin, Mechanistic Aspects and Applications. Acc. Chem. Res. 2018, DOI: 10.1021/acs.accounts.8b00151
- Jin, K.; Li, X.* Advances in NCL-Desulfurization: A powerful strategy for peptide and protein synthesis. Chem. Eur. J. 2018, DOI: 10.1002/chem.201802067
- Cui, Z.; Zhu, B.; Li, X.*; Cao, H.* Access to Sulfonylated Furans or Imidazo[1,2-]pyridines via a Metal-free Three-component, Domino Reaction. Front. Org. Chem. 2018, 5, 2219.
- Yang, D.; Yu, Y.; Wu, Y.; Feng, H.; Li, X.*; Cao, H.* One-Pot Regiospecific Synthesis of Indolizines: A Solvent-free, Metal-free, Three-Component Reaction of 2-(Pyridin-2-yl)acetates, Ynals and Alcohols or Thiols. Org. Lett. 2018, 20, 2477.
- Xu, C.; Xu, J.; Li, X.* Development of aspartic acid ligation for peptide cyclization derived from serine/threonine ligation. Chin. Chem. Lett. 2018, 29, 1119.
- Cheng, Y.; Li, X.; Tse, H. F.; Rong, J. Gallic Acid-L-Leucine Conjugate Protects Mice against LPS-Induced Inflammation and Sepsis via Correcting Proinflammatory Lipid Mediator Profiles and Oxidative Stress. Oxid. Med. Cell. Longev. 2018, 1081287
- Jin, K.; Po, K. H. L.; Kong, W. Y.; Lo, C. H.; Lo, C. W.; Lam, H. Y.; Sirinimal, A.; Reuven, J. A.; Chen, S.; Li, X.* Synthesis and antibacterial studies of teixobactin analogues with non-isostere substitution of enduracididine. Bioorg. Med. Chem. 2018, 26, 1062. (Kong, W. Y., Lo, C. H.; Lo, C. W.; Lam, H. Y.; Sirinimal, A., Reuven, J. A. are undergraduates).
- Wang, C.; Lai, J.; Chen, C.; Li, X.*; Cao, H.* J.(2017). Ag-Catalyzed Tandem Three-Component Reaction toward the Synthesis of Multisubstituted Imidazoles.
- Jin, K., Li, T., Chow, H. Y., Liu, H &Li, X.* (2017). P‐B desulfurization: an enabling method for protein chemical synthesis and site‐specific deuteration. Angewandte Chemie International Edition. [Pubmed]
- Liu, H., Zhang, Y., Wei, R., Andolina, G., & Li, X.* (2017). Total Synthesis of Pseudomonas aeruginosa 1244 Pilin Glycan via de novo Synthesis of Pseudaminic Acid. Journal of the American Chemical Society. [Pubmed]
- Jin, K.; Po, K. H. L.; Wang, S.; Reuven, J. A.; Wai, C. N.; Lau, H. T.; Chan, T. H. Chen, S.*; Li, X.*Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation. Bioorg. Med. Chem. 2017, 17, 30587. (Wang, S., Reuven, J. A., Wai, C. N., Lau, H. T., and Chan, T. H are undergraduates)
- Lin, D.; Lam, H. Y.; Han, W.; Cotroneo, N.; Pandya, B. A.*; Li, X.* Structure-activity relationship of daptomycin analogues with substitution at (2S, 3R) 3-methyl glutamic acid position. Bioorg. Med. Chem. Lett. 2017, 3, 456. ( Han, W. is an undergraduate student)
- Cheng Y, Feng Y, Xia Z, Li X, Rong J. Biochim Biophys Acta. 2017, 1862(12):1595-1605
- Cheng, Y. Y.; Luo, D.; Xia, Z.; Tse, H. F.; Li, X.; Rong, J.* Arch. Immunol. Ther. Exp. (Warsz). 2017, 65, 145.