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Teaching Staff

Professor ZHANG, Jiangwen

Professor ZHANG, Jiangwen

Associate Professor, School of Biological Sciences, Faculty of Science, HKU

BSc(Wuhan University); MPhil (Johns Hopkins University); PhD (Johns Hopkins University, School of Medicine)

  • 3917 3341
  • 2858 3477
  • KBSB 7N06

Teaching Areas

  • Omics and Systems Biology
  • Genetics
  • Stem cell and Regenerative Biology
  • From molecules to cells

Research Interests

  • Cancer
  • Epigenetics/genetic of cancer
  • Bioinformatics
  • Gene regulatory network
  • Signaling pathways
  • Cancer omics
  • Cancer drug development

Current Research

  • Non-coding RNA in cancer
  • Chromatin remodeler in cancer
  • microRNA in cancer
  • Drug combination against cancer
  • Cancer gene database
  • Cancer genetics
  • Omics tool development

Research Team

Eva Chiu      Technician, School of Biological Sciences

Beibei Ru      PhD candidate, School of Biological Sciences

Yin Tong      PhD candidate, School of Biological Sciences

Qingzheng Kang      PhD candidate, School of Biological Sciences

Yunxing Huang      PhD candidate, School of Biological Sciences

Publications and News

  • Ru B*, Sun J*, Kang Q, Tong Y, Zhang J. (2018) A framework for identifying dysregulated chromatin regulators as master regulators in human cancer. Bioinformatics. bty836. (*co-first author)

 

  • Chen M, Zhang J, Berger AH, Diolombi MS, Ng C, Fung J, Bronson RT, Castillo-Martin M, Thin TH, Cordon-Cardo C, Plevin R, Pandolfi PP. (2018) Compound haploinsufficiency of DOK2 and DUSP4 cooperates to promote lung tumorigenesis. Journal of Clinical Investigation. (accepted)

 

  • Ru B, Tong Y, Zhang J. (2018) MR4Cancer: a web server prioritizing master regulators for cancer. Bioinformatics. bty658

 

  • Tong Y*, Sun J*, Wong CF, Kang Q, Ru B, Wong CN, Chan AS, Leung SY, Zhang J. (2018) MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis. Genome Biology. 19:73. (*co-first author)

 

  • Tong Y, Ru B, Zhang J. (2018) miRNACancerMAP: an integrative web server inferring miRNA regulation network for cancer. Bioinformatics. bty320.

 

  • Ru B, Sun J, Tong Y, Wong CN, Chandra A, Tang ATS, Chow LKY, Wun WL, Levitskaya Z, Zhang J. (2018) CR2Cancer: a database for chromatin regulators in human cancer. Nucleic Acids Research. 46(D1):D918-D924.

 

  • Chen M, Zhang J, Sampieri K, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM, Menon AV, Webster KA, Ng C, Palumbieri MD, Diolombi MS, Breitkopf SB, Teruya-Feldstein J, Signoretti S, Bronson RT, Asara JM, Castillo-Martin M, Cordon-Cardo C, Pandolfi PP. (2018) An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nature Genetics. 50:206-18.

 

  • Bezzi M, Seitzer N, Ishikawa T, Reschke M, Chen M, Wang G, Mitchell C, Ng C, Katon J, Lunardi A, Signoretti S, Clohessy JG, Zhang J, Pandolfi PP. (2018) Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. Nature Medicine. 24:165-75.

 

  • Chen M, Wan L, Zhang J, Zhang J, Mendez L, Clohessy J, Berry K, Victor J, Yin Q, Yuan Z, Wei W, Pandolfi PP. (2018) Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nature Communications. 9:159.
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