Professor LAM K M Andy
Assistant Professor, School of Biological Sciences, Faculty of Science, HKU
MSc (Bath); DPhil (Oxford)
- [javascript protected email address]
- 3917 3310
- 2858 3477
- KBSB 5N-11
Teaching Areas
- Membrane Biophysics
- Structural Biology
- Molecular Pharmacology
Research Interests
- Cryo-Electron Microscopy
- Electrophysiology
- Membrane Transport
- Ion Channel Structure and Mechanism
Current Research
- Ligand gating in TMEM16 proteins
- Structural pharmacology of TMEM16 proteins
Fellowships
- Young Investigator Grant (Novartis Foundation for Medical-Biological Research)
- Forschungskredit Postdoctoral Fellowship (University of Zurich)
Publications and News
Key publications:
^ corresponding author, * equal contribution
- Lam AK^ & Dutzler R^. Mechanistic basis of ligand efficacy in the calcium-activated chloride channel TMEM16A. The EMBO Journal (2023) e115030https://dx.doi.org/10.15252/embj.2023115030
- Lam AK^, Rutz S & Dutzler R^. Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC. Nature Communications13, 2798 (2022) http://dx.doi.org/10.1038/s41467-022-30479-1
- Lam AK^ & Dutzler R^. Mechanism of pore opening in the calcium-activated chloride channel TMEM16A. Nature Communications12, 786 (2021) http://dx.doi.org/10.1038/s41467-020-20788-8
- Lam AK^, Rheinberger J, Paulino C^ & Dutzler R^. Gating the pore of the calcium-activated chloride channel TMEM16A. Nature Communications12, 785 (2021) http://dx.doi.org/10.1038/s41467-020-20787-9
- Lam AK& Dutzler R. Calcium-dependent electrostatic control of anion access to the pore in the calcium-activated chloride channel TMEM16A. eLife 2018;7:e39122 https://dx.doi.org/10.7554/eLife.39122
- Deneka D*, Sawicka M*, Lam AK, Paulino C & Dutzler R. Structure of a volume-regulated anion channel of the LRRC8 family. Nature 2018 May 16. http://dx.doi.org/10.1038/s41586-018-0134-y
- Paulino C, Kalienkova V, Lam AK, Neldner Y & Dutzler R. Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM. Nature 552, 21-425 (21 December 2017) http://dx.doi.org/10.1038/nature24652
Awards and Honours
- Clarendon Scholarship (University of Oxford)
- New College Scholarship (New College, University of Oxford)