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Teaching Staff

Dr. CHAN, Gary Ying Wai

Dr. CHAN, Gary Ying Wai

School of Biological Sciences, Faculty of Science, HKU

BSc (HKUST, HK); MPhil (HKUST, HK); PhD (University of Basel, Switzerland)


  • 22990849
  • 25599114
  • KBSB 4N11

Teaching Areas

  • Genetics
  • DNA repair

Research Interests

  • Chromosome segregation and genome instability,
  • Mechanism of homologous recombination
  • Mechanism of enzymes involved DNA repair and segregation

Current Research 

  • How DNA repair intermediates pose a threat to chromosome segregation and genome instability
  • Molecular mechanism of the formation and resolution of ultrafine anaphase bridges
  • Function and mechanism of nucleases involved in DNA repair and segregation

Fellowships 

  • EMBO Long-Term Fellowship (2013-2015)

Publications and News

  • Chan, Y.W., Fugger, K., and S.C. West. 2018. Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations. Nature Cell Biology 20, 92-103
  • Shah Punatar, R., Martin, M. J., Wyatt, H. D. M., Chan, Y. W., and West, S. C. 2017. Resolution of single and double Holliday junction recombination intermediates by GEN1. Proceedings of the National Academy of Sciences of the United States of America 114, 443–450
  • Chan, Y.W. and S.C. West. 2015. GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism. Nucleic Acid Research. 43 (22): 10882-10892.
  • Chan, Y.W. and S.C. West. 2014. Spatial control of the GEN1 Holliday junction resolvase ensures genome stability. Nature Comms. 5: 5844.
  • For all publications, see lab website: https://sites.google.com/site/garychanlab/