Mechanism of enzymes involved DNA repair and segregation
How DNA repair intermediates pose a threat to chromosome segregation and genome instability
Molecular mechanism of the formation and resolution of ultrafine anaphase bridges
Function and mechanism of nucleases involved in DNA repair and segregation
EMBO Long-Term Fellowship (2013-2015)
Publications and News
Chan, Y.W., Fugger, K., and S.C. West. 2018. Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations. Nature Cell Biology 20, 92-103
Shah Punatar, R., Martin, M. J., Wyatt, H. D. M., Chan, Y. W., and West, S. C. 2017. Resolution of single and double Holliday junction recombination intermediates by GEN1. Proceedings of the National Academy of Sciences of the United States of America 114, 443–450
Chan, Y.W. and S.C. West. 2015. GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism. Nucleic Acid Research. 43 (22): 10882-10892.
Chan, Y.W. and S.C. West. 2014. Spatial control of the GEN1 Holliday junction resolvase ensures genome stability. Nature Comms. 5: 5844.
For all publications, see lab website: https://sites.google.com/site/garychanlab/