A method for peritoneal metastatic cell detection and isolation
Year: 2019
Inventor: Professor Alice S T Wong et al.
A microfluidic chip for early detection of peritoneal metastatic cancer cells.
Year: 2019
Inventor: Professor Alice S T Wong et al.
A microfluidic chip for early detection of peritoneal metastatic cancer cells.
Year: 2019
Inventor: Professor Billy KC Chow and Dr Kailash Singh
KSD179019 has great potential as a novel class of anti-hypertensive drug for the treatment of hypertension, particularly for patients who are not responsive to current drug regime. The application of this small molecule as an anti-hypertension drug has already been approved by the University of Hong Kong (HKU) Patent committee for filing the US provisional patent (O/Ref: IP00835). This technology is currently licensed to a pharmaceutical startup, PhrmaSec Limited, which is a biotech spinoff company from HKU.
Year: 2019
Inventor: Professor Xuechen Li and others
A new method for producing cyclic peptides fordrug discovery applications.
Year: 2019
Inventor: Professor Hongzhe Sun and others
US provisional patent on silver and gold compounds as a mobile colistin resistant proteins (MCRs) inhibitor to overcome infections by superbugs.
Year: 2019
Inventor: Professor Xiang David Li and others
Functionalized peptides as YEATS domain inhibitors with potential anti-leukemia activity.
Year: 2018
Inventor: Dr Hani El-Nezamy and others
The subject invention pertains to probiotic compositions and methods of treating hepatocellular carcinoma (HCC) using the probiotic compositions. The probiotic compositions can inhibit growth of HCC. The probiotic compositions can reduce the risk of HCC. The probiotic compositions include a specific combination of three bacterial compositions: (a) heat-inactivated Lactobacillus rhamnosus GG deposited under accession number ATCC 53103, also known as, Lactobacillus acidophilus (Moro) Hansen and Macquot, (b) viable Escherichia coli Nissle 1917, and (c) heat-inactivated VSL#3.RTM.. This combination of bacteria is effective to reduce hepatocellular carcinoma (HCC) growth compared to control growth.
Year: 2015 / 2013
Inventor: Professor Che Chi Ming
Solid-supported gold nanoparticles for use as a catalyst for the synthesis of quinolines from anilines and aldehydes using oxygen as an oxidant are provided. Also provided are a method for the preparation of SiO2-supported gold nanoparticles by in situ deposition of gold nanoparticles to silica gel and a method for synthesizing quinolines from anilines and aldehydes using oxygen as an oxidant.
Year: 2015
Inventor: Dr Li Xuechen and others
A method for the synthesis of daptomycin or a daptomycin analogue is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogues can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogues can include a different fatty acid in the side arm of the daptomycin analogue.
Year: 2014
Inventor: Professor Yang Dan and and others
Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.
Year: 2014
Inventor: Professor Che Chi Ming
Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.
Year: 2014
Inventor: Professor Che Chi Ming and others
Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growthin vivo.
Year: 2012 / 2011
Inventor: Professor Yang Dan and others
Compounds which exhibit antiviral activity, particularly against influenza virus,and methods of making and using there of are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteralor parenteral administration. The compounds are preferably used to treat or prevent Influenza Ainfections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.
Year: 2012 / 2011
Inventor: Professor Che Chi Ming and others
A method for treatment of cancer by inhibiting the activity of histone deacetylase, comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of a gold(III) complex having the structural formula of or a pharmaceutically acceptable salt thereof, wherein: -R is selected from the group consisting of -OH, -CH2OH, C2H4OH, -C3H6OH or -C4H8OH; and X is independently a pharmaceutically acceptable counter-ion.
Year: 2012 / 2011
Inventor: Professor Che Chi Ming and others
A pharmaceutical composition comprising one or more of the following ruthenium oxalate compounds Formulae (I , II , III , and IV) as an active ingredient . The pharmaceutical composition can be used for the treatment of viral-infected patients or prophylactic treatment of patients at risk from viral infection .
Year: 2012 / 2011 / 2010 / 2009 / 2007
Inventor: Professor Che Chi Ming and others
A pharmaceutical composition comprising one or more of the following ruthenium oxalate compounds Formulae (I , II , III , and IV) as an active ingredient . The pharmaceutical composition can be used for the treatment of viral-infected patients or prophylactic treatment of patients at risk from viral infection .
Year: 2011 / 2009
Inventor: Professor Yang Dan and others
Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and /or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.
Year: 2011
Inventor: Dr Li Xuechen and others
A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (Fig. 1 (a)): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond.
Year: 2011
Inventor: Professor Che Chi Ming and others
The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.
Year: 2011
Inventor: Professor Che Chi Ming and others
Disclosed is the use of gold (III) complexes of porphyrins, Schiff-bases, bis(pyridyl)carboxamides and bis(pyridyl)sulfonamides as anti-tumor and anti-HIV agents.
Year: 2011 / 2009
Inventor: Professor Yang Dan and others
Provided herein are 5-demethoxyfumagillol and its derivatives. Also provided herein are methods of making the 5-demethoxyfumagillol and derivatives. Also provided herein are biological activities of the 5-demethoxyfumagillol and derivatives and methods of using same for treating diseases.
Year: 2010
Inventor: Professor Che Chi Ming and others
The present invention relates to lanthanide porphyrin complexes and their uses as anti-tumor agents. The described complexes show promising cytotoxic properties toward cancer cells in both in vitro and in vivo studies.
Year: 2010 / 2009 / 2008
Inventor: Professor Yang Dan and others
Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
Year: 2009 / 2008
Inventor: Professor Che Chi Ming and others
Gold(III) phosphine complexes [Au.sub.m(CNC).sub.mL].sup.n+ (where HCNCH=2,6-diphenylpyridine) and their use as anti-tumor agents are disclosed. Notable results for the appearance of new potential anti-tumor application of these gold(III) complexes are reported. The described complexes show promising cytotoxic properties toward cancer cells in both in vitro and in vivo studies.
Year: 2009 / 2008 / 2007 / 2006
Inventor: Professor Che Chi Ming and others
This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.
Year: 2009 / 2007
Inventor: Professor Che Chi Ming and others
Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.
Year: 2005
Inventor: Professor Che Chi Ming and others
Disclosed is the use of gold (III) complexes of porphyrins, Schiff-bases, bis(pyridyl)carboxamides and bis(pyridyl)sulfonamides as anti-tumor and anti-HIV agents.