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Healthcare - Issued patents / Published patent applications

Method and compositions for treating cancer using pro

Year: 2018

Inventor: Dr Hani El-Nezamy and others

The subject invention pertains to probiotic compositions and methods of treating hepatocellular carcinoma (HCC) using the probiotic compositions. The probiotic compositions can inhibit growth of HCC. The probiotic compositions can reduce the risk of HCC. The probiotic compositions include a specific combination of three bacterial compositions: (a) heat-inactivated Lactobacillus rhamnosus GG deposited under accession number ATCC 53103, also known as, Lactobacillus acidophilus (Moro) Hansen and Macquot, (b) viable Escherichia coli Nissle 1917, and (c) heat-inactivated VSL#3.RTM.. This combination of bacteria is effective to reduce hepatocellular carcinoma (HCC) growth compared to control growth.

Solid supported gold nanoparticles, methods of use thereof, and methods for making same

Year: 2015 / 2013

Inventor: Professor Che Chi Ming

Solid-supported gold nanoparticles for use as a catalyst for the synthesis of quinolines from anilines and aldehydes using oxygen as an oxidant are provided. Also provided are a method for the preparation of SiO2-supported gold nanoparticles by in situ deposition of gold nanoparticles to silica gel and a method for synthesizing quinolines from anilines and aldehydes using oxygen as an oxidant.

Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue

Year: 2015

Inventor: Dr Li Xuechen and others

A method for the synthesis of daptomycin or a daptomycin analogue is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogues can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogues can include a different fatty acid in the side arm of the daptomycin analogue.

Antifungal compound and uses thereof

Year: 2014

Inventor: Professor Yang Dan and and others

Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.

Method of using binuclear gold (i) compounds for cancer treatment

Year: 2014

Inventor: Professor Che Chi Ming

Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.

Novel gold (III) complexes containing n-heterocyclic carbene ligand, synthesis, and their applications in cancer treatment and thiol detection

Year: 2014

Inventor: Professor Che Chi Ming and others

Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growthin vivo.

Antiviral compounds and methods of making and using thereof

Year: 2012 / 2011

Inventor: Professor Yang Dan and others

Compounds which exhibit antiviral activity, particularly against influenza virus,and methods of making and using there of are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteralor parenteral administration. The compounds are preferably used to treat or prevent Influenza Ainfections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.

Hydroxy-substituted cold(III) porphyrin complexes as histone deacetylase inhibitors

Year: 2012 / 2011

Inventor: Professor Che Chi Ming and others

A method for treatment of cancer by inhibiting the activity of histone deacetylase, comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of a gold(III) complex having the structural formula of or a pharmaceutically acceptable salt thereof, wherein: -R is selected from the group consisting of -OH, -CH2OH, C2H4OH, -C3H6OH or -C4H8OH; and X is independently a pharmaceutically acceptable counter-ion.

Pharmaceutical composition containing cyclometalated n-heterocyclic carbene complexes for cancer treatment

Year: 2012 / 2011

Inventor: Professor Che Chi Ming and others

A pharmaceutical composition comprising one or more of the following ruthenium oxalate compounds Formulae (I , II , III , and IV) as an active ingredient . The pharmaceutical composition can be used for the treatment of viral-infected patients or prophylactic treatment of patients at risk from viral infection .

Pharmaceutical composition having a ruthenium oxalato compound and method of using the same

Year: 2012 / 2011 / 2010 / 2009 / 2007

Inventor: Professor Che Chi Ming and others

A pharmaceutical composition comprising one or more of the following ruthenium oxalate compounds Formulae (I , II , III , and IV) as an active ingredient . The pharmaceutical composition can be used for the treatment of viral-infected patients or prophylactic treatment of patients at risk from viral infection .

Method of modulating membrane potential of a cell

Year: 2011 / 2009

Inventor: Professor Yang Dan and others

Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and /or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.

Native chemical ligation at serine and threonine sites

Year: 2011

Inventor: Dr Li Xuechen and others

A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (Fig. 1 (a)): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond.

Nitridoosmium(VI) complexes for treatment of cancer

Year: 2011

Inventor: Professor Che Chi Ming and others

The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.

Pharmaceutical compositions for induction of apoptosis of cancer cells and inhibition of reverse transcriptase of human immunodeficiency virus-1

Year: 2011

Inventor: Professor Che Chi Ming and others

Disclosed is the use of gold (III) complexes of porphyrins, Schiff-bases, bis(pyridyl)carboxamides and bis(pyridyl)sulfonamides as anti-tumor and anti-HIV agents.

5-demethoxyfumagillol and derivatives thereof

Year: 2011 / 2009

Inventor: Professor Yang Dan and others

Provided herein are 5-demethoxyfumagillol and its derivatives. Also provided herein are methods of making the 5-demethoxyfumagillol and derivatives. Also provided herein are biological activities of the 5-demethoxyfumagillol and derivatives and methods of using same for treating diseases.

Lanthanide-porphyrin complexes as anti-tumor agents

Year: 2010

Inventor: Professor Che Chi Ming and others

The present invention relates to lanthanide porphyrin complexes and their uses as anti-tumor agents. The described complexes show promising cytotoxic properties toward cancer cells in both in vitro and in vivo studies.

Synthetic ion channels

Year: 2010 / 2009 / 2008

Inventor: Professor Yang Dan and others

Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.

Anti-Cancer phosphine containing [Auiiim(Cnc)Ml]N+ complexes and derivatives thereof and methods for treating cancer using such compositions

Year: 2009 / 2008

Inventor: Professor Che Chi Ming and others

Gold(III) phosphine complexes [Au.sub.m(CNC).sub.mL].sup.n+ (where HCNCH=2,6-diphenylpyridine) and their use as anti-tumor agents are disclosed. Notable results for the appearance of new potential anti-tumor application of these gold(III) complexes are reported. The described complexes show promising cytotoxic properties toward cancer cells in both in vitro and in vivo studies.

Diazene-bridged crown ether lithium compounds and methods for their use

Year: 2009 / 2008 / 2007 / 2006

Inventor: Professor Che Chi Ming and others

This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.

Di(Amido-Substituted) heteroarene compounds as osteoblastogenesis agents

Year: 2009 / 2007

Inventor: Professor Che Chi Ming and others

Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.

Gold (III) complexes as anti-tumor and anti-HIV agents

Year: 2005

Inventor: Professor Che Chi Ming and others

Disclosed is the use of gold (III) complexes of porphyrins, Schiff-bases, bis(pyridyl)carboxamides and bis(pyridyl)sulfonamides as anti-tumor and anti-HIV agents.