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Teaching Staff

Professor XIE, Ting

Professor XIE, Ting

Professor, Chair of Stem Cell Biology, School of Biological Sciences, Faculty of Science, HKU

Ph.D., Molecular Biology and Biochemistry (Rutgers University), M.S., Plant Genetics and Breeding (China Agricultural University), B.S., Plant Genetics and Breeding (China Agricultural University)

    • 3917 3830
    • 2858 3477
    • KBSB 4N09

    Teaching Areas

    • Stem cell biology
    • Developmental biology
    • Developmental genetics

     

    Research Interests

    • Stem cell biology
    • Germ cell development
    • Tissue regeneration
    • Age-related retinal degenerative diseases
    • Stem cell therapy
    • Gene therapy
    • Aging
    • Age-related kidney diseases

     

    Current Research

    • Stem cell-niche interactions and self-renewal mechanisms
    • Inter-tissue communications in stem cell regulation
    • Niche control of stem cell lineage differentiation
    • RNA modifications in stem cells and tissues
    • Glaucoma pathogenic mechanisms
    • Gene therapy for glaucoma
    • Stem cell therapy for photoreceptor degeneration
    • Mechanisms underlying membranous nephropathy
    • Aging and age-related diseases

     

    Research Team

    My research team is composed of research assistant professor, postdoctoral fellows, postgraduate students and research assistants

     

    Publications

    • Xie T, Spradling AC. A niche maintaining germ line stem cells in the Drosophila Ovary. Science. 2000; 290:328-330.

    • Song X, Zhu CH, Doan C, Xie T.  Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science. 2002; 296:1855-1857.

    • Xi R, Xie T. Stem cell self-renewal controlled by chromatin remodeling factors. Science. 2005; 310:1487-1489.

    • Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary. Cell Stem Cell. 2007; 1:458-469.

    • Li T, Lewallen M, Chen S, Yu W, Zhang N, Xie T. Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells. Cell Res. 2013; 23(6):788-802.

    • Pan L, Wang S, Lu T, Weng C, Song X, Park JK, Sun J, Yang ZH, Yu J, Tang H, McKearin DM, Chamovitz DA, Ni J, Xie T. Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014; 514(7521):233-6.

    • Ma X, Zhu X, Han Y, Story B, Do T, Song X, Wang S, Zhang Y, Blanchette M, Gogol M, Malanowski K, Peak A, Anoja P, Xie T. Aubergine controls germline stem cell self-renewal and progeny differentiation via distinct mechanisms. Developmental Cell 2017; 41(2):157-169.

    • Zuo F, Tu R, Duan B, Yang Z, Ping Z, Song X, Chen S, Price A, Li H, Scott A, Perera A, Li S, Xie T. Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. Proc Natl Acad Sci U S A. 2020 Feb 18; 117(7): 3603-3609.

    • Tu R, Duan B, Song X, Xie T. Glypican Dlp-mediated Hedgehog and Wnt signaling interdependence is crucial in the niche for germline stem cell progeny differentiation. Science Advances. 2020 May 4; aaz0480.

    • Tu, R, Tang, XA, Xu R, Ping Z, Yu Z, Xie T. Gap junction-transported cAMP from the niche controls stem cell progeny differentiation. Proc Natl Acad Sci U S A. 2023 August 21; 120 (35): e2304168120

     

    Awards and Honours

    • The HKUST Faculty Recognition
    • Hong Kong Global STEM Professorship
    • M. R. and Evelyn Hudson Foundation prize
    • Howard Hughes Medical Institute Postdoctoral Fellow
    • Busch Predoctoral Fellowship

     

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