Professor LIU Nan

Teaching Areas

• Structural Biology
• Biochemistry and Biophysics
• Cryo-Electron Microscopy and Structural Determination
• Protein Science

Research Interests

• Cryo-Electron Microscopy
• Protein Structures and Dynamics
• In-Situ Structural Analysis
• AI for Structural Biology

Current Research

• Cryo-electron microscopy methodology development
• Nanomaterials
• In-situ structural analysis of membrane proteins

Resarch Team

• Ms. Tse Mei Ying, Iris
• Dr Ren Jiahao

Fellowships

• Young Scientists Fund (National Natural Science Foundation of China)
• Outstanding Postdoctoral Fellowship of Tsinghua University
• Shuimu Tsinghua Scholar (Tsinghua University)
• Advanced Innovation Fellow, Beijing Advanced Innovation Center for Structural Biology
• Outstanding Graduate of Beijing

Publications and News

(^#equal contribution; *corresponding author)

• Liu N, Wang HW*. (2024) Graphene in cryo-EM specimen optimization. Current Opinion in Structural Biology. (Review) 86:102823. DOI: 10.1016/j.sbi.2024.102823
• Xu J^#, Gao XY^#, Zheng LM^#, Jia X, Xu K, Ma YW, Wei XD, Liu N*, Peng HL*, Wang HW*. (2024) Graphene sandwich-based biological specimen preparation for cryo-EM analysis. Proceedings of the National Academy of Sciences. 121(5):e2309384121. DOI: 10.1073/pnas.2309384121. Featured in Research Highlights by Nature Methods.
• Cheng H^#, Zheng LM^#, Liu N^#, Huang CY, Xu J, Lu Y, Cui XY, Xu K, Hou Y, Tang JC, Zhang Z, Li J, Ni XD, Chen YN*, Peng HL*, Wang HW*. (2023) Dual-affinity graphene sheets for high-resolution cryo-electron microscopy. Journal of the American Chemical Society. 145(14): 8073–8081. DOI: 10.1021/jacs.3c00659.
• Zheng LM^#, Liu N^#,*, Gao XY^#, Zhu WQ, Yan R, Zhang JC, Gao X, Yao YT, Deng B, Xu J, Lu Y, Wei XD*, Wang HW*, and Peng HL*. (2023) Uniform thin ice on ultraflat graphene for high-resolution cryo-EM. Nature Methods. 20:123–130. DOI: 10.1038/s41592-022-01693-y.
• Liu N and Wang HW*. (2023) Better Cryo-EM Specimen Preparation: How to Deal with the Air–Water Interface? Journal of Molecular Biology 435(9):167926. DOI: 10.1016/j.jmb.2022.167926. (Review)
• Su S^#, Wang J^#, Deng T, Yuan X, He J, Liu N, Li XM, Huang Y, Wang HW*, Ma JB*. (2022) Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature. 607(7918):399-406. DOI: 10.1038/s41586-022-04911-x.
• Lu Y^#, Liu N^#,*, Liu YB^#, Zheng LM^#, Yang JH, Wang J, Zi QR, Peng HL*, Rao Y*, Wang HW*. (2022) Functionalized graphene grids with various charges for single-particle cryo-EM. Nature Communications. 13(1):6718. DOI: 10.1038/s41467-022-34579-w.
• Chen J^#, Liu N^#, Huang YP^#, Wang YX^#, Sun YX^#, Wu QC, Li DR, Gao SH, Wang HW*, Huang N*, Qi XB*, and Wang XD*. (2021) Structure of PDE3A–SLFN12 Complex and Structure-based Design for A Potent Apoptosis Inducer of Tumor Cells. Nature Communications. 12, 6204. DOI: 10.1038/s41467-021-26546-8. Featured in Editors’ Highlights.
• Liu N^#, Dong XD^#, Hu CX, Zeng JW, Wang JW, Wang J, Wang HW*, Belfort M*. (2020) Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Research. 48(19):11185-11198. DOI: 10.1093/nar/gkaa773.
• Liu N^#,Zhang JC^#, Chen YN^#,*, Liu C, Zhang X, Xu K, Wen J, Luo ZP, Chen SL, Gao P, Jia KC, Liu ZF, Peng HL*, Wang HW*. (2019) Bioactive functionalized monolayer graphene for high-resolution cryo-electron microscopy. Journal of the American Chemical Society 141, 4016-4025. DOI: 10.1021/jacs.8b13038. Featured in Spotlights in JACS publications.

Full publication list:

https://scholar.google.com/citations?hl=zh-CN&user=jkL6NhgAAAAJ

Awards and honours

• Outstanding Young Scholar Award (優秀青年學者獎), Chinese Electron Microscopy Society, 2024