Professor CHAN, Chi Bun

• Endocrinology
• Lipid and glucose metabolism
• Gene regulation
• Exercise physiology
• Obesity
• Insulin resistance
• Aging
• Signal transduction

Current Research

• Studying the effect of myokines in muscle aging and energy metabolism
• Identification of novel signaling molecules in lipid and glucose metabolism
• Developing novel compounds to treat metabolic syndromes

Research Team

• Ms. Elsie Chit Yu Iu
• Ms. Coco Miaojia Hang
• Dr Wai Hung Sit
• Dr Margaret Tse
• Ms. Iris Ching Yee Yii
• Ms, Jenny Lin Zhang

Publications and News

Complete list of published work in NCBI MyBibliography:

https://www.ncbi.nlm.nih.gov/sites/myncbi/12WgcKXSDsYAE/bibliography/43196358/public/?sort=date&direction=ascending

•  Ahuja P., Bi X, Ng C.F., Tse M.C.L., Hang M., Pang B.P.S, Iu E.C.Y., Chan W.S., Ooi X.C., Sun A., Herlea-Pana O., Liu Z., Yang Y., Jiao B., Ma X., Wu K.K.L., Lee L.T.O., Cheng K.K.Y., Lee C.W. and Chan C.B. Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-fibroblast growth factor pathway. Hepatology 2023 77: 213-229.
• Yan R., Choi V.W.W., Hartono T., Tse I.M.Y., Tse M.C.L., Zhou Y., Xu J., Sit W.H., Wan J.M.F., Li E.T.S., Chan C.B. and Louie J.C.Y. Effect of lifelong sucrose consumption on food intake and body composition of C57BL/6N mice. Frontiers in Nutrition 2022 9: 1076073.
• Liu P., Wang Z., Kang S.S., Liu X., Chan C.B. and Ye K. High-fat Diet-induced Diabetes Couples to Alzheimer’s Disease through Inflammation-activated C/EBPβ/AEP Pathway. Molecular Psychiatry 2022 27: 3396-3409.
• Law S.T.S., Nong W., So W.L., Seale T., Chan C.B., Tobe S.S., Kai Z., Bendena W., Hayward A., and Hui J.H.L. Chromosomal level reference genome of the moth Heortia vitessoides (Lepidoptera: Crambidae), a pest of agarwood-producing trees. Genomics 2022 114: 110440.
• Wang H., Xu H, Chen W., Cheng M., Zou L., Yang Q., Chan C.B., Zhu H., Chen C., Nie J. and Jiao B. Rab13 sustains breast cancer stem cells by supporting tumor-stroma crosstalk. Cancer Research 2022 82: 2124-2140.
• Ahuja P., Ng C.F., Pang B.P.S., Chan W.S., Tse M.C.L., Bi X., Kwan H.L.R., Brobst D., Herlea-Pana O., Yang X., Du G., Saengnipanthkul S., Noh H.L., Jiao B., Kim J.K., Lee C.W., Ye K. and Chan C.B. Muscle-generated BDNF (brain-derived neurotrophic factor) maintains mitochondrial quality control in diet-induced obesity. Autophagy 2022 18: 1367-1384
• Kundi Z.M., Lee J.C.Y., Pihlajamaki J., Chan C.B., Leung K.S., So S. S. Y., Kolehmainen M. and El-Nezami H. Dietary fiber from Oat and Rye Brans ameliorate Western-diet induced body weight gain and hepatic inflammation by the modulation of short-chain fatty acids, bile acids, and tryptophan metabolism Molecular Nutrition & Food Research 2021 65:e1900580
• Chan C.K., Kwan H.L.R., Wong Y.S., Jiang Z., Zhou Z., Tam K.W., Chan Y.S., Chan C.B. and Lee C.W. Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs. eLife 2020 9:e54379 .
• Jia W., Wang N., Yin L., Chen X., Hou B., Wang J., Qiang G., Chan C.B., Yang X. and Du G. Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice. Biology of Sex Differences 2020 11:9
• Jiang X., He M., Bai J., Chan C.B. and Wong A.O.L. Signal transduction for TNFα-induced type II SOCS expression and its functional implication in growth hormone resistance in Carp hepatocytes. Frontiers in Endocrinology 2020 11:20. doi: 10.3389/fendo.2020.00020
• Bai J., Jiang X., He M., Chan C.B. and Wong A.O.L. Novel mechanisms for IGF-I regulation by glucagon in carp hepatocytes: up-regulation of HNF1alpha and CREB expression via signaling crosstalk for IGF-I gene transcription. Frontiers in Endocrinology 2019 10: 605.
• Yang X., Brobst D., Chan W.S., Tse M.C.L., Herlea-Pana O., Ahuja P., Bi X., Zaw A.M., Kwong Z.S.W., Jia W., Zhang Z., Zhang N., Chow S.K.H., Cheung W.H., Louie J.C.Y., Griffin T.M., Nong W., Hui J.H.L., Du G., Noh H.L., Saengnipanthkul S., Chow B.K.C., Kim J.K., Lee C.W. and Chan C.B. Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility Science Signaling 2019 12: eaau1468.
• Jia W., Wang N., Lin Y., Chen X., Hou B., Qiang G., Chan C.B., Yang X., and Du G. Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice. Biochemical and Biophysical Research Communications 2019 514: 407-414.
• Chen T., Wong M.K.H., Chan C.B. and Wong A.O.L. Mechanisms for temperature modulation of feeding in goldfish and implications on seasonal changes in feeding behavior and food intake. Frontiers in Endocrinology 2019 10: 133
• Zhang S., Sheng H., Zhang X., Qi Q., Chan C.B., Li L., Shan C. and Ye. K. Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation. Cell Death & Disease 2019 10: 222-234
• Yang X., Tse M.C.L., Hu X., Jia W., Du G., and Chan C.B. Interaction of CREB and PGC-1α induces fibronectin type III domain-containing protein 5 expression in C2C12 myotubes. Cellular Physiology and Biochemistry 2018 50: 1574-1584.
• Wood J., Tse M.C.L., Yang X., Brobst D., Liu Z., Pang B.P.S., Chan W.S., Zaw A.M., Chow B.K.C.C., Ye K., Lee C.W. and Chan C.B. BDNF Mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle. Metabolism – Clinical and Experimental 2018 87: 113-122.