Research Output Prize 2018-19
Professor Xiang David LI
Department of Chemistry
Professor David Li was awarded the University's Research Output Prize 2018-19 with the jornal paper "Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking", Nature Chemical Biology, 2018, Vol. 14, pp. 1140-1149 by Xin Li, Xiao-Meng Li, Yixiang Jiang, Zheng Liu, Yiwen Cui, Ka Yi Fung, Stan H. E. van der Beelen, Gaofei Tian, Liling Wan, Xiaobing Shi, C. David Allis, Haitao Li, Yuanyuan Li, Xiang David Li.
Professor Li received his BSc degree from Fudan University in 2003, and his PhD from the University of Hong Kong in 2008. After three years undertaking postdoctoral work at the Rockefeller University in New York, he joined HKU’s Department of Chemistry in 2011 as an Assistant Professor, and was promoted to Associate Professor in 2017.
Professor Li’s research is at the interface of chemistry and biology. He develops novel chemical approaches to address key questions in epigenetics, a research area linking multiple hereditary and environmental impacts on our health. His most important contribution to this research field is the development of a variety of new and robust chemical tools and methodologies to unravel how any modification of histones, the chief protein components of the genome, affects gene activity and expression in normal physiology and disease pathogenesis. The findings from Professor Li’s research should ultimately improve our understanding of human diseases (e.g. cancer) linked to errors in epigenetic processes and may lead to the design of new and improved therapeutic strategies.
Congratulations to Professor Li for his receiving of the award.